Struggling duo VVV Venlo and Willem II Tilburg both suffered defeat as NEC Nijmegen were held at home by Roda JC Kerkrade.
Eredivisie basement side VVV-Venlo's abysmal start to the season continued as they were hammered 4-1 at home against fellow strugglers NAC Breda.
The visitors were out of sight by half-time, with an eighth minute strike from Kees Luyckx setting them on their way while Elson Hooi doubled their lead after 28 minutes - just three minutes before Uche Nwofor pulled one back for VVV.
Danny Verbeek extended NAC's two-goal cushion in the 39th minute before Anthony Lurling completed the scoring on the stroke of half-time as NAC claimed their second win of the season to move into third from bottom above Willem II, who were beaten 2-0 at ADO Den Haag.
Willem II were holding their own until Jordens Peters was dismissed in the 61st minute.
Danny Holla netted from the spot immediately after and Mike van Duinen sealed all three points for Den Haag two minutes from time.
In Saturday's other game, NEC Nijmegen were held to a goalless draw at home to Roda JC.