Premier League participants Tim Howard, Brad Guzan and Geoff Cameron have made USA's provisional 30-man World Cup squad.
Goalkeepers Howard and Guzan, who turn out for Everton and Aston Villa respectively, are joined by Stoke City defender Cameron.
Sunderland striker Jozy Altidore has also been selected by coach Jurgen Klinsmann despite a difficult season at the Stadium of Light which saw him net just twice in all competitions.
Former Fulham and Tottenham Hotspur forward Clint Dempsey forms part of a large MLS contingent, along with LA Galaxy stalwart Landon Donovan - a man well known to Everton supporters.
Experienced frontman Eddie Johnson, who helped to fire the United States through their qualification campaign, is among the surprise omissions.
USA's provisional 30-man squad:
Goalkeepers: Brad Guzan (Aston Villa), Tim Howard (Everton), Nick Rimando (Real Salt Lake)
Defenders: DaMarcus Beasley (Puebla), Matt Besler (Sporting Kansas City), John Brooks (Hertha Berlin), Geoff Cameron (Stoke City), Timmy Chandler (Nuremberg), Brad Evans (Seattle Sounders FC), Omar Gonzalez (LA Galaxy), Clarence Goodson (San Jose Earthquakes), Fabian Johnson (Hoffenheim), Michael Parkhurst (Columbus Crew), DeAndre Yedlin (Seattle Sounders FC)
Midfielders: Kyle Beckerman (Real Salt Lake), Alejandro Bedoya (Nantes), Michael Bradley (Toronto FC), Joe Corona (Club Tijuana), Brad Davis (Houston Dynamo), Mix Diskerud (Rosenborg), Maurice Edu (Philadelphia Union), Julian Green (Bayern Munich), Jermaine Jones (Besiktas), Graham Zusi (Sporting Kansas City)
Forwards: Jozy Altidore (Sunderland), Terrence Boyd (Rapid Vienna), Clint Dempsey (Seattle Sounders FC), Landon Donovan (LA Galaxy), Aron Johannsson (AZ Alkmaar), Chris Wondolowski (San Jose Earthquakes)