The Football Association has confirmed that Chelsea duo Frank Lampard and Ryan Bertrand will miss England's World Cup qualifier away to Poland.
The pair missed Friday's win over San Marino but boss Roy Hodgson was hoping they would be available for the crucial second game of the current double-header on Tuesday.
However, after reporting to England's Watford training base on Sunday afternoon, it has been decided neither player will be able to feature.
"Frank Lampard and Ryan Bertrand have been ruled out of England's FIFA World Cup qualifier with Poland," read an England statement.
"Lampard (calf) and Bertrand (illness) did not take part in England's 5-0 win over San Marino, and will not be ready for Tuesday's game.
"Roy Hodgson and his squad of 23 players travel to Warsaw on Monday morning."
Theo Walcott had already been ruled out of the clash in Warsaw after suffering a chest injury in a collision with San Marino goalkeeper Aldo Simoncini.