The Spanish and Italian leagues drew to a close with respective champions Real Madrid and Juventus crowning their title-winning campaigns with final day wins.
There was also relegation drama throughout the leagues, with Villarreal dropping out of La Liga after a surprise plummet down the table.
Montpellier closed on the Ligue 1 title in France, while Gary Hooper was a five-goal hero for Celtic in the Scottish Premier League.
Villarreal suffered a final day to forget after a 1-0 defeat at Atletico Madrid sealed their shock relegation from La Liga, with Falcao netting a late winner for the hosts.
At the other end of the table, Malaga secured the final UEFA Champions League spot with a 1-0 victory at home to Sporting Gijon, staving off the threat of Atletico Madrid and Levante.
Champions Real Madrid reached a century of points as they signed off their triumphant season with a home win over Real Mallorca, with Mesut Ozil netting a brace, while outgoing coach Pep Guardiola's final league match with Barcelona ended in 2-2 draw at Real Betis.
Italian champions Juventus smashed AC Milan's record of 42 matches unbeaten as they finished their undefeated campaign with a 3-1 triumph over Atalanta.
The win marked Juve icon Alessandro Del Piero's final game for the club and he crowned it with a goal as he bid an emotional farewell to the Old Lady.
Another goodbye came in AC Milan's 2-1 win over relegated Novara as veteran striker Filippo Inzaghi ended his Rossoneri career in style with a late winner off the bench.
Udinese cemented a third-place finish and secured UEFA Champions League football after beating Catania 2-0, while Lecce's relegation was confirmed after they suffered a 1-0 defeat at Chievo.
Montpellier are on the brink of Ligue 1 glory after snatching a last-gasp victory over Lille, with substitute Karim Ait-Fana poaching a 94th minute winner.
The win means Montpellier lead Paris St German by three points with one game remaining after the capital club beat Rennes 3-0 at home, with Nene notching a hat-trick.
Rock-bottom Auxerre's survival hopes were snuffed out after they were beaten 3-0 at mid-table Marseille.
In the promotion/relegation play-offs, De Graafschap slipped into the second tier after they were beaten on away goals by FC Den Bosch.
VVV-Venlo kept their survival hopes alive after securing an aggregate win over Cambuur Leeuwarden and advance to the final play-off round.
RKC Waalwijk and Vitesse Arnhem will meet in the Eredivisie UEFA Europa League play-off final after they saw off competition from FC Twente and NEC Nijmegen respectively.
Gary Hooper hit all five of Celtic's goals in a remarkable performance as they topped off their title-winning season with a 5-0 thrashing of Hearts.
Rangers' Sone Aluko was also in prolific form, netting a hat-trick as the club thumped St Johnstone 4-0.
Best of the rest
Primeira Liga champions FC Porto finished their season with a win, beating Rio Ave 5-2 as Kleber scored a hat-trick.
Benfica finish second and six points adrift of the winners, ending their season with a 3-1 triumph at Vitoria Setubal.