Argentina remain top of the South American World Cup qualifying group despite being held to a 1-1 draw by Peru in Lima.
Carlos Zambrano had put the hosts in front after 22 minutes, but they should have already been ahead but Claudio Pizarro missed an early penalty.
Argentina did manage to salvage a point with Real Madrid star Gonzalo Higuain firing home just before the break.
Despite having the likes of Higuain, captain Lionel Messi, Ezequiel Lavezzi and Angel di Maria in their starting XI - Alejandro Sabella's side could not find a winner.
Salomon Rondon's double gave Venezuela a shock 2-0 victory at Paraguay.
Rondon struck in either half as Venezuela moved into sixth in the table on 11 points, just one below Chile, who occupy the last automatic qualifying position at the moment.
Radamel Falcao put in a man of the match display as Colombia came from a goal down to claim a surprise 3-1 win at Chile .
In an encounter that saw both sides reduced to 10 men, Atletico Madrid striker Falcao scored one and set up another as Colombia remained in second place in the table.
Colombia are now on 13 points in the CONMEBOL qualifying zone, the same as Ecuador, who played out a 1-1 draw with Uruguay in Montevideo.
Former Manchester City striker Felipe Caicedo put Ecuador ahead with a seventh minute penalty before Edinson Cavani gave the Uruguayans a share of the spoils in the 66th minute.
However, the hosts were a perhaps a touch fortunate after keeper Fernando Muslera appeared to foul Cristian Benitez in the area.
Referee Carlos Amarilla refused to award a penalty and Ecuador then saw Manchester United midfielder Antonio Valencia sent off in injury-time.