Aiden McGeady has withdrawn from the Republic of Ireland squad to take on Wales in next week's friendly.
The Spartak Moscow winger, named in a provisional 26-man party last month, has a knee injury and will not feature.
He joins David Forde, Stephen Quinn, Anthony Pilkington and Simon Cox in pulling out.
Wednesday's meeting at the Cardiff City Stadium is the first between the countries since February 2011.
The Irish won 3-0 on that occasion, but Chris Coleman's side are coming into the game on the back of three wins in five games.