Chelsea midfielder Frank Lampard has been ruled out of England's World Cup qualifier against San Marino at Wembley tonight.
The Blues star had been struggling with a knee injury ahead of the Group H encounter and has now returned to the Stamford Bridge side for further treatment.
Chelsea team-mate Ryan Bertrand has also been ruled out as he is suffering from a sore throat which has not improved sufficiently.
The duo are scheduled to re-join Roy Hodgson's party at the weekend for a further check-up to see if they are fit to feature in Tuesday's testing clash against Poland in Warsaw.
"Frank had a scan earlier in the week and tried to train apart from the team but do a bit more on Wednesday morning, and he still felt a slight problem with his calf," said Hodgson.
"It was re-scanned and they found a few fibres where there's been a slight tear. It's not a major problem but it was decided the best thing is to let him go back to his club to get treatment on a daily basis there, and we'll re-assess on Sunday.
"When Ryan Bertrand fell ill we were hoping it would just be one of those 24-hour things but it's turned out to be a bit more of a serious illness than that. It is purely illness and again, we hope to recover him on Sunday along with