Wilfried Zaha and Carl Jenkinson could be set to win their first England caps after being called into the squad for Wednesday's friendly against Sweden.
Roy Hodgson's party has been hit with a string of withdrawals following the weekend's Premier League action, leading to call ups for Zaha, Jenkinson and Tom Huddlestone for the clash in Stockholm.
Hodgson was left short of attacking options when Wayne Rooney and Theo Walcott were ruled out after picking up knocks at the weekend.
Rooney was withdrawn in the 79th minute of Manchester United's 3-2 win over Aston Villa with an ankle injury while Walcott sustained a muscular problem during Arsenal's 3-3 draw with Fulham.
And Hodgson has also lost the Tottenham defender Kyle Walker and winger Aaron Lennon, who suffered injuries in the defeat to Manchester City.
Liverpool's Jonjo Shelvey has also been withdrawn after the midfielder did not feature in the squad which drew 1-1 at Chelsea on Sunday.
There are also concerns over Steven Gerrard, who injured his knee at Stamford Bridge, and should he miss out Joe Hart will wear the captain's armband.
Hodgson also made enquiries about adding Jermain Defoe and Alex Oxlade-Chamberlain to the squad but was informed by Tottenham and Arsenal, respectively, that neither player was fit.
The England coach is still awaiting clearance from FIFA that Jenkinson can be included as the Arsenal full-back has previously played for Finland at U19 level.
Zaha has been rewarded for his fine form for his club which has helped propel Crystal Palace to the top of the Championship table.
The highly-rated 20-year-old has often stated his desire to play for Ivory Coast, the country of his birth, and his inclusion in a friendly for England would not affect his eligibility.
Huddlestone has won three caps since making his debut for England in 2009.