Stephen Kelly will captain the Republic of Ireland in their friendly clash with Uruguay on Tuesday night.
The Fulham defender takes the armband from Robbie Keane who will not play a part after being released by boss Giovanni Trapattoni, who will use the game to look at some of his backup players.
Kelly, 27, was an unused substitute in the 2-1 victory over Macedonia in Euro 2012 qualifying on Saturday night.
Meanwhile, Trapattoni has made a number of other changes to his side with only Keiren Westwood, Darren O'Dea and Kevin Foley remaining in the starting XI.
Republic of Ireland team to play Uruguay:
Westwood, Foley, Kelly, O'Dea, Clark, Lawrence, Green, Fahey, Keogh, McCarthy, Long