Estonia will be without striker Andres Oper when they tackle England in a Euro 2008 qualifier later this month.
The news of Oper's absence is a massive blow as he is the country's all-time leading goalscorer with 32 goals.
With Vladimir Voskoboinikov also injured and Indrek Zelinski having retired, head coach Viggo Jensen is lacking experience up front.
Kritsen Viikmae has been called into the squad as Estonia look for revenge following their 3-0 home defeat back in June.
However, the European minnows cannot qualify for Euro 2008 after winning just one of their 10 qualifiers to date.