PSV Eindhoven have been knocked out of the Europa League at the group stage after a home defeat to Chornomorets.
The Dutch side knew a draw at home would be enough to see them into the last 32 but Franck Dja Djedje's 59th-minute winner sent Ukrainian side Chornomorets through at their expense.
The visitors were reduced to 10 men when Sito Rieira was sent off with three minutes remaining but PSV were unable to capitalise.
Bulgarian side Ludgorets underlined their status as group winners with a 2-1 win at Dinamo Zagreb, thanks to goals from Duje Cop and Roman Bezjak.
Spanish side Valencia are also into the next round after a 1-1 draw with Kuban Krasnodar in Group A, which also spelled the end for the Russian side in the competition.
Salzburg secured their 100% record in Group C as two goals from Sadio Mane and one from Kevin Kampl gave them a 3-0 win over Esbjerg, who also qualified in second place.
In Group D, Rubin Kazan were already assured top spot and wrapped up their group campaign with a 2-0 win over Zulte Waregem in Belgium.
Fiorentina beat Dnipro Dnipropetrovsk 2-1 to top Group E, although both teams qualified.
Eintracht Frankfurt secured a 2-0 win over APOEL to top Group F, while Maccabi Tel Aviv made sure of second place with Eran Zahavi's late penalty giving them a 1-0 win over Bordeaux in Israel.
Dinamo Kiev beat Rapid Vienna to qualify, although Genk took top spot in Group G thanks to a 1-0 win at Thun.
Sevilla and Slovan Liberec both progressed from Group H courtesy of wins at Freiburg and Estoril-Praia respectively.
In Group I, Lyon topped the group after winning 2-1 at Vitoria Guimaraes, with Real Betis, who drew 0-0 with HNK Rijeka taking second.
AZ Alkmaar drew 2-2 with Paok Salonika in Group L, with both sides having already secured their progress.