Prestatyn Town suffered a 3-0 second-leg defeat against Rijeka as their Europa League campaign was ended by an 8-0 aggregate thrashing.
The Welsh side trailed 5-0 after the first-leg of the second round qualifying tie and Ivan Mocinic stretched the Croatian's healthy advantage at Rhyl.
Ivan Boras added a second before Goran Mujanovic completed the rout in the second half.
Derry City were also on the end of a heavy aggregate loss, losing 7-2 over two legs against Turkish side Trabzonspor.
The hosts had impressed in a battling 4-2 loss in the first leg, but hopes of a heroic fight back were ended by Paulo Henrique's two goals after the break.
Abdulkadir Ozdemir completed the scoring for Trabzonspor in injury time.
Linfield also bowed out as 10-man FC Xanthi battled for an away-goals win in extra time at Windsor Park.
Pereira Marcelinho wiped out Linfield's 1-0 first-leg advantage in the 27th minute and the Irish side could not hit back in normal time, despite the dismissal of Konstantinos Fliskas just before the break.
The hosts did regain the lead in the 99th minute through Michael Gault's volley, but Marcelinho added his second in the 105th minute to make it 2-2 on aggregate and send Xanthi through on away goals.