Panathinaikos dumped out Roma, Villarreal suffered an exit to Wolfsburg, while Werder Bremen thumped four past FC Twente.
An interesting night in the Europa League also saw Standard Liege sneak into the last 16 as they drew at Red Bull Salzburg to seal a 3-2 aggregate score, while Valencia disposed of Club Brugge.
Greek outfit Panathinaikos secured a 6-4 aggregate win over Roma in another pulsating Europa League encounter.
The Greek side took a 3-2 lead from the first leg to the Stadio Olimpico but the Italian's looked in control of the tie when former Liverpool fullback John Arne Riise's 30-yard strike deflected in off the post.
Panathinaikos then struck three times in the space of five minutes to stun Roma and book a place in the Europa League last 16 with Riise's former Reds teammate Djibril Cisse scoring from the spot on 40 minutes.
Sotiris Ninis (43) fired a right-footed strike from the edge of the area past Roma keeper Doni before Cisse (45) sealed his brace by rounding the keeper after being teed up by Ninis.
Roma dominated after the restart and reduced the arrears in the 67th minute through Daniele De Rossi. Tzorvas parried another Riise strike but only as far as Italy midfielder who tapped in from close range.
The home side were unable to strike again and never looked liked scoring the five required once Panathinaikos had grabbed their third on the night as the score finished up just as it did in Greece.
In Germany, meanwhile, Werder Bremen overturned a one goal deficit to seal a 4-2 aggregate score over Steve McClaren's FC Twente with a 4-1 win on Thursday night.
The Dutch outfit lead 1-0 from their home leg, but Bremen wasted no time in stamping their authority in the tie as they raced into a three goal lead on the night through a Claudio Pizarro (15, 20) brace and Brazilian Naldo's (27) effort.
Teenage striker Luke de Jong pulled (33) one back for Twente to bring them back into the tie on aggregate, but former Chelsea strike Pizarro sealed his hat-trick shortly before the hour mark to comfortably send the Germans through to the last 16.
Elsewhere in Germany, Bundesliga outfit Wolfsburg knocked out Spanish side Villarreal with a 6-3 aggregate score following their 4-1 win in the Volkswagen Arena.
The side's drew 2-2 in the first leg, and Edin Dzeko (9) edged the German outfit in front inside ten minutes before Villarreal defender Angel (14) put through his own net to put the home side in control of the tie.
Joan Capdevilla (30) got the Spaniards back in with a shout of taking the game to extra time with his goal on the half hour mark but those hopes were quashed by Christian Gentner's (41) strike four minutes before the break.
Grafite added gloss to the win as he struck a fourth for Wolfsburg on 64 minutes
Elsewhere, Standard Liege edged through 3-2 on aggregate after battling to a 0-0 draw at Red Star Salzburg. The Belgians took an unconvincing score to the Bullen-Arena having conceded two away goals.
They were unable to cancel out any of the goals conceded at home, but an all round stalemate saw them creep into the last 16 of the tournament.
Meanwhile, Valencia kept the Spanish flag flying but they required extra time to knock Club Brugge out in a 3-1 aggregate score.
With the Belgians holding a 1-0 lead from their home leg, Juan Mata evened things up in the first minute of the Mestalla leg, but the hosts where unable to build on their early success and extra time was needed at the end of the 90.
The Spanish side didn't hang about long after the re-start as Hernandez Pablo grabbed a 97th minute goal to put Valencia in control. And the midfielder strengthened his side's grip on the game with another three minutes from time in a 3-0 win on the night.