Real Madrid centre-back Pepe faces a race against time to be fit for the Champions League final after being diagnosed with a calf injury in his left leg.
Real have not revealed how long the Portugal international, who has formed a solid partnership with Spain's Sergio Ramos this season, will be out of action for, but reports suggest he will be on the sidelines for around two weeks.
Real play city rivals Atletico Madrid in the May 24 showpiece in Lisbon and have two more La Liga matches before then - Sunday's game at Celta Vigo and a home clash with Espanyol on the final day of the season.
Pepe, 31, who has a grade one injury in his left calf, is set to miss both La Liga fixtures, putting his participation in the Champions League final in doubt.
If either Pepe or Ramos are out, Real coach Carlo Ancelotti usually starts with France defender Raphael Varane, whose appearances have been limited this season following a serious knee injury.
Atletico are currently top of the La Liga table on 88 points, three ahead of defending champions Barcelona, with Real a point further back in third.
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