St Patrick's Athletic's Europa League adventure was finished off by Hannover as Inter Milan survived a scare to advance to the final qualifying round.
Marseille and FC Twente made smooth progress to the next stage, but last season's runners-up Athletic Bilbao had to hang on to negotiate their passage onwards.
Irish side St Pat's were always going to be up against in their second leg against Hannover after a 3-0 defeat at home and followed that up with a 2-0 reverse in Germany.
Karim Haggui opened the scoring for Hannover just past the half-hour mark before Mario Eggiman netted the second goal two minutes after half-time.
Inter Milan scrambled through to the next stage 3-2 on aggregate after suffering a surprise 2-0 home defeat at the hands of Hajduk Split.
Ante Vukusic's penalty broke the deadlock midway through the first half and Ivan Vukovic netted on 58 minutes, but the Croatians were unable to find a third goal to take the tie to extra-time.
Athletic Bilbao lost 2-1 away to Slaven Belupo in the second leg, but the 2011/12 finalists edged through 3-2 on aggregate.
Alen Moras had given Slaven a 28th minute lead and, after Ikier Muniain levelled just after the break, the hosts scored again throuh Mario Gregurina.
Andre Ayew scored a goal in each half as Marseille cruised to a 3-0 home success over Eskisehirspor to go through 4-1 on aggregate.
Ayew netted either side of a 36th minute goal from Andre-Pierre Gignac, while Marseille played the final 15 minutes with 10 men after Benoit Cheyrou was sent off.
FC Twente are safely through after first-half goals from Nacer Chadli and Leroy Fer earned a 2-0 win at Mlada Boleslav and a 4-0 aggregate triumph.
Eredivisie rivals Heerenveen are also in the next round after a 1-0 defeat at Rapid Bucharest only led to a 4-1 aggregate scoreline.
However, fellow Dutch side Vitesse Arnhem bowed out of the competition after a 2-0 home defeat by big-spending Russian outfit Anzhi Makhachkala.
Samuel Eto'o scored three minutes after half-time before the former Barcelona and Inter Milan striker converted a late penalty to round off a 4-0 aggregate win.