PSV Eindhoven won 6-1 at NAC Breda on Saturday to reclaim top spot in the Eredivisie table, as Heerenveen beat Vitesse.
Jeremain Lens set PSV on their way with a brace in the 11th and 17th minutes and, after NAC had halved the deficit through Jordy Buijs, the visitors made it 3-1 just before the half-hour thanks to Georgino Wijnaldum.
Mathias Jorgensen further extended PSV's advantage in the 37th minute before second-half goals from Luciano Narsingh and his replacement Jurgen Locadia sealed the victory.
The result lifts PSV back above FC Twente on goal difference with their title rivals having beaten AZ Alkmaar on Friday night.
Vitesse Arnhem missed the chance to replace Ajax in the top three ahead of the champions' match with FC Utrecht on Sunday as they were beaten 2-1 at Heerenveen.
Goals from Heerenveen duo Filip Djuricic (30 minutes) and Alfred Finnbogason (50) sandwiched an equaliser from Guram Kashia (39) as stumbling Vitesse were left with just one point from their last three games.
Seventh-placed NEC Nijmegen are also going through a bad patch and their winless run stretched to four matches after they fell to a 2-0 defeat at ADO Den Haag.
NEC were reduced to 10 men in the 22nd minute when Kevin Conboy was handed his marching orders and ADO took full advantage through a brace from Jens Toornstra (33 and 86).
Saturday night's other Eredivisie match saw Heracles draw 1-1 at home with
PEC Zwolle, the hosts taking a 15th-minute lead through Samuel Armenteros only to be pegged back by Youness Mokhtar's equaliser 12 minutes later.