PSV Eindhoven skipper Mark van Bommel has warned the Eredivisie leaders will be more focused for their visit to Ajax after seeing their winning run ended last weekend.
This season's surprise packets Vitesse Arnhem delivered their latest shock with a 2-1 win at the Philips Stadion to halt a run of eight successive wins.
That has left PSV just two points ahead of the chasing pack ahead of their trip to the capital to take on the champions this Saturday.
Van Bommel believes, however, that the defeat has done them good as they look to open a nine-point gap over Frank de Boer's fourth-placed side.
"It is so much better for us now because we know what we need to do in Amsterdam," the veteran midfielder told De Telegraaf. "We are not too worried. If we had played badly and created nothing then there would have been reason for concern."
Should PSV slip up FC Twente or Vitesse could replace them at the top of the standings.
Twente host mid-table ADO Den Haag on Saturday while Vitesse will know where they stand when lowly Roda JC, without a win in six, visit the GelreDome a day later.
Roda technical director Gerard Wielaert admitted ahead of the game that his side will need to bolster their squad in the winter transfer window.
"I am confident that we can get out of the relegation places, but I do think we could use some extra players," he told Voetbal International.
"We will only be interested in players who really add something and preferably those who will remain at Roda. There is certainly no panic though."
Fifth-placed Feyenoord will look to extend a three-game winning run, which has included clean sheets in their past two, when they welcome RKC Waalwijk to Rotterdam.
Rock-bottom Willem II ended a five-game losing run with a draw at home to Heracles last weekend and will look to pick up more points at home to Heerenveen.
There is a relegation battle on Friday night when second-from-bottom VVV-Venlo travel to promoted Zwolle.
The pick of Sunday's games will see FC Utrecht, whose good early-season form has started to dip, play host to an AZ Alkmaar side without a win in four.
NEC Nijmegen are at home to struggling NAC Breda while Heracles will look to bounce back from a disappointing result against Willem II at Groningen.