Go Ahead Eagles took the scalp of Excelsior in the Dutch Cup on Tuesday.
Willem II sidestepped a potential banana skin as they proved too good for Be Quick 28, but Excelsior were not so fortunate against lower league opposition.
Late goals from Sjoerd Ars and Rence van der Wal helped Go Ahead Eagles progress at the expense of Excelsior.
Yves Heskamp scored twice for Be Quick, but his efforts proved in vain as Willem II replied on five occasions to progress.
The all-Eredivisie tie went the way of NAC Breda who claimed a 3-1 win at Groningen.
Groningen are flying high in the Eredivisie, but goals from Edwin de Graaf, Mike Zonnelveld and Leonardo handed NAC a 3-1 win.
De Graafschap left it late to see off Emmen, with a goal from Jhonny van Beukering securing victory for the home side.
RBC Roosendaal were too strong for FC Eindhoven, while MVV Maastricht saw off the challenge of Stormvogels Telstar.