Vitesse Arnhem and FC Twente will be hoping the speculation surrounding Frank de Boer's future will have an unsettling effect on Ajax in the final match before the Eredivisie winter break.
Vitesse are currently top - two points ahead of Ajax - with a trip to Heracles ahead of them on Saturday by which point they may have been dislodged with Twente facing RKC Waalwijk on Friday.
De Boer has been heavily linked with Premier League side Tottenham who are searching for a new manager following the sacking of Andre Villas-Boas on Monday.
His agent Guido Albers played down the speculation and told Voetbal International: "Through various channels it has become clear to me that Spurs are interested, but the club has not approached Ajax.
"So for us there is not much to say about it. Frank focuses entirely on Ajax."
Leaders Vitesse Arnhem will be looking to take advantage of any slip by Ajax while also asking for an immediate response to their exit from the KNVB Beker when they travel to Heracles.
Vitesse went down 3-1 to Roda JC on Wednesday night, a surprising result given their respective positions in the league as well as their recent form.
Peter Bosz's side have enjoyed six successive victories in the league while Roda have suffered three defeats in a row but there were few complaints from the leaders.
Bosz told Omroep Gelderland: "Roda were much better.
"I noticed after a few minutes that the team was not good. We lost almost all the duels."
Neither did he give any credence to the notion the team were tired, saying: "Nonsense. If in a week you can not play three games you should choose another profession.
"Then you bring it on yourself."
Were Twente to win on Friday they would go top on goal difference although they now face opponents who have two wins and two draws from their last four matches.
Twente though are on a run of four successive wins themselves and it is an intriguing tussle.
Ajax - currently second - do not play until Sunday when they travel to face Roda.
The Amsterdam side have won their last five games and scored 16 goals in the process while conceding just one.
However, the hosts will be hoping the speculation surrounding De Boer's future will have an unsettling effect.
Feyenoord are three points behind Ajax and have a home game against FC Zwolle, who are looking for their first win since October 20.
After that, just 11 points separate Heerenveen in fifth and bottom side NEC Breda.
Heerenveen travel to AZ Alkmaar who will leapfrog their visitors with victory.
The other game on Saturday sees NAC take on second bottom SC Cambuur Leeuwarden.
The remaining three matches on Sunday see PSV Eindhoven host ADO Den Haag, FC Groningen face bottom side NEC and Go Ahead Eagles play FC Utrecht.