FC Twente maintained their three-point lead at the top of the Eredivisie with a 3-0 win at home to nine-man AZ Alkmaar.
Nacer Chadli put Steve McClaren's men in front on 20 minutes and AZ shot themselves in the foot twice in consecutive minutes early in the second half.
The visitors had Adam Maher sent off in the 51st minute and Jozy Altidore dismissed a minute later and after that it was just a question of how many Twente would get.
Dusan Tadic got the second courtesy of a 60th-minute penalty and Luc Castaignos added a third two minutes later.
PSV Eindhoven moved level on points with Vitesse Arnhem in second with a 4-0 romp at home to NAC Breda.
Jeremain Lens put PSV in front in the 24th minute and Ola Toivonen got a second just before the break.
Veteran midfielder Mark van Bommel grabbed the third 11 minutes after the break and Georgino Wijnaldum completed the rout five minutes from time.
Champions Ajax slipped up as they were held 1-1 at home to FC Utrecht to fall five points off the early pace.
Ryan Babel put the Amsterdammers ahead in the sixth minute, but Fabian Sporkslede's own goal just five minutes after coming on ensured a share of the spoils.