Feyenoord enjoyed a home victory over Eredivisie title hopefuls PSV Eindhoven as leaders AZ Alkmaar were thrashed by Heerenveen, and FC Twente and Vitesse Arnhem both recorded big wins.
Goals either side of half-time from Sekou Cisse and Ruben Schaken earned Feyenoord a 2-0 success over PSV at De Kuip.
Cisse's low finish made the breakthrough for the hosts four minutes before the interval and Schaken's goal five minutes into the second half sealed the win.
Table-topping AZ suffered only a second defeat of the season after being hammered 5-1 away from home by Heerenveen.
Bas Dost gave Heerenveen a 14th minute lead and, after Jozy Altidore had drawn AZ level on 20 minutes, the hosts regained the initiative through Rajiv van La Parra on 31 minutes.
Filip Djuricic and Ramon Zomer scored within the opening three minutes of the second half to put Heerenveen out of sight before Luciano Narsingh added a fifth goal on 74 minutes.
FC Twente closed to within a point of second-placed PSV after an emphatic 6-2 success away to FC Utrecht.
Goals from Peter Wisgerhof and Ola John inside the opening 13 minutes put Twente in control before substitute Willem Janssen scored on 47 and 58 minutes.
John notched his second of the game on 63 minutes before Utrecht rallied through goals from Frank Demouge and Davy Bulthuis.
However, another Twente substitute had the final say in a high-scoring encounter as Steven Berghuis scored the visitors' sixth goal with seven minutes left.
Vitesse remain in the mix for a European qualification place after posting an impressive 4-0 home triumph over lowly RKC Waalwijk.
Jan-Arie van der Heijden set Vitesse on their way with a ninth minute opener before Vako Kaziashvili added the second on 21 minutes.
Stanley Aborah scored the third just before half-time and Wilfried Bony's goal before the hour mark rounded off the scoring.