Vitesse Arnhem hammered PSV 6-2 to stay on top of the Eredivisie and pile more pressure on defiant Eindhoven coach Phillip Cocu.
The scoreline did flatter Vitesse, who scored three in the last six minutes but Cocu's men stay down in tenth place after their sixth defeat of the season and they have now not won since 6 October.
Lucas Piazon scored the opener in Eindhoven before Memphis Depay pulled PSV level at the end of the first half.
Goals by Mike Havenaar and Kelvin Leerdam looked to have sealed the three points for Vitesse but Karim Rekik cut the margin to one goal in the 84th minute.
But as they chased an equaliser they got caught on the break, not just once, but three times. Patrick Van Aanholt (87) and Davy Propper (85 & 90) rubbed salt in PSV's wounds.
"However tough it is, I am a club man. I love the club and I am here for the players," Cocu said. "I'm not the type to throw in the towel."
Ajax, in second, warmed up for their crucial midweek Champions League clash with AC Milan by thrashing NAC Breda 4-0 thanks to a hat-trick by midfielder Davy Klaassen.
Klaassen, who is running into form after recovering from a long groin injury, scored in the 34th minute, in stoppage time at the end of the first half and then again in the 64th minute before Bojan Krkic rounded off the rout four minutes later.
"We produced great attacks and beautiful goals. It's a shame we didn't score more," Ajax coach Frank de Boer said.
Ajax have to beat AC Milan in Milan on Wednesday to progress to the knockout stages of the Champions League.
Third-placed FC Twente had to wait until stoppage time for the winner in their 2-1 victory at AZ Alkmaar.
Roy Beerens gave AZ the lead in just the third minute, controlling the ball on his chest and volleying home before Youness Mokhtar turned the match around with a goal in the 39th minute and the last-gasp winner.
Elsewhere, 10-man RKC Waalwijk salvaged a 2-2 draw at home to Cambuur Leeuwarden.
Robert Braber opened the scoring for the hosts but a first-half double from Michiel Hemmen saw 14th-placed Cambuur turn the game on its head.
Sander Duits levelled from the penalty spot in the 54th minute and 17th-placed RKC survived the late dismissal of Damiano Schet to hold onto a valuable point.