PSV Eindhoven and FC Twente narrowed the gap at the top of the table, as AZ Alkmaar's six-match winning streak came to an end against Ajax.
AZ Alkmaar have surged clear of their rivals in recent weeks with a strong run of form and looked set to make it seven straight victories against defending champions Ajax, only to be pegged back to 2-2.
AZ went 2-0 up thanks to first-half goals by Brett Holman and Roy Beerens, before Ajax clawed back a point after the break with a penalty by Miralem Sulejmani and Theo Janssen's strike eight minutes before the final whistle.
Ajax midfielder Eyong Enoh was sent off for two bookable offences, but AZ failed to use their man advantage, meaning Ajax remain fourth in the table with 16 points.
PSV Eindhoven have not been beaten since the opening day of the season but were made to work hard for a 1-0 victory over FC Utrecht.
The score was goalless until deep into the second half, before Ola Toivonen broke the deadlock for PSV on 71 minutes.
Utrecht could not respond and their misery was compounded just before the final whistle as Marcus Nilsson was shown a straight red card.
The result leaves PSV just two points adrift of leaders AZ, while Utrecht continue to occupy a mid-table berth.
FC Twente are level with PSV in second following a convincing 4-0 victory away to RKC Waalwijk.
Marc Janko was the Twente hero with a hat-trick, while Wout Brama grabbed the other goal in an impressive demolition of a side that had also been going well this season.
Heracles Almelo continue to head the right way in the Eredivisie standings after beating FC Groningen 2-1 to extend their unbeaten stretch to four games.
Lerin Duarte opened the scoring for the home side in the 29th minute, before Hyun-Jun Suk equalised for Groningen in the final quarter of the match.
However, Willie Overtoom sealed the win for Heracles 10 minutes from the final whistle to consign Groningen to their first league defeat in four games.
Heerenveen and De Graafschap played out a 1-1 draw in the day's final fixture as Sven Kums' opener for the hosts was cancelled out by Michael de Leeuw just a minute later.