Tournament favourites Juventus have been drawn to play Lyon in the quarter-finals of the Europa League next month.
The Italian champions beat Serie A rivals Fiorentina to reach the last eight and are pursuing a place in the final on their home ground in Turin.
Next in the way are a Lyon side beaten in this season's Champions League qualifiers and currently fifth in the French league - 25 points behind leaders Paris St Germain.
Elsewhere Benfica's reward for eliminating Tottenham is a tie with AZ Alkmaar of Holland, while 2011 winners Porto play Sevilla.
The remaining tie matches Valencia with Swiss side Basel, who failed to make it out of the Champions League group stage this season despite twice beating Chelsea.
AZ Alkmaar v Benfica
Lyon v Juventus
Basel v Valencia
Porto v Sevilla
Matches to be played on April 3 and April 10.