PSV Eindhoven host Vitesse in the Eredivisie on Sunday, while Ajax are away to Roda JC and Twente take on FC Zwolle.
Winger Jeremain Lens has announced his intention to quit PSV in the summer ahead of this weekend's Eredivisie action- but he hopes to sign off with another title success.
Lens joined PSV, after winning the league at AZ Alkmaar, in 2010 and has established himself as a regular in the Holland squad due to some fine displays at the Philips Stadion.
But the 24-year-old believes now is the time to seek a fresh challenge - preferably abroad.
He told Elf Voetbal Magazine: "At the end of this season, I will be 25 and then a transfer must come.
"I would like to leave PSV with the title but if that does not happen it is still no reason to stay.
"At this point in my career I need to go for my career and personal development.
"I don't have a real preference for a particular league but in terms of playing style, England and Germany would suit me."
Lens' wish of another title in Holland could be realised with PSV currently leading the table with a three-point advantage over FC Twente.
On Sunday, they host third-placed Vitesse Arnhem, who are five points off the summit.
And Dick Advocaat's men will certainly not underestimate their opponents - Vitesse's last away game was a 2-0 win at Ajax.
The fourth-placed Amsterdammers will look to bounce back from a humbling 4-1 defeat to Borussia Dortmund in the Champions League in midweek when
they go to struggling Roda JC.
The omens look good with Roda having conceded 10 goals in their last two
The top four teams are all in action on Sunday with second-placed FC Twente taking on PEC Zwolle in Enschede.
Steve McClaren's men have stumbled slightly of late and draws in their last two games - against Vitesse and FC Utrecht - have seen them slip off top spot.
Zwolle beat NAC Breda last weekend to pull away from the lower reaches while the result also prompted a managerial change in Breda with former player Nebojsa Gudelj taking over.
Gudelj's first game in charge will be Friday night's home clash with ADO Den Haag.
On Saturday, rock-bottom Willem II will look to end a run of five successive defeats when they host Heracles, second-bottom VVV-Venlo meet Heerenveen, FC Groningen go to RKC Waalwijk and seventh-placed NEC take on FC Utrecht in Nijmegen.
Sunday's remaining game sees Feyenoord visit AZ Alkmaar.
The Rotterdammers will again be without midfielder Kevin Leerdam who has been ostracised by coach Ronald Koeman after refusing to sign a new deal.
Koeman admits, however, the situation is far from ideal.
"It gives me pain," he told NUsport.
"Leerdam is a player who has always behaved correctly and did the maximum for Feyenoord but at some point I had to come to a decision in the best interests of the club."