Second-placed Vitesse Arnhem lost ground in the Eredivisie title race on Saturday as they went down 2-1 at home to PSV Eindhoven, who climbed to third in the standings as a result.
With leaders Ajax not in action until they visit NAC Breda on Sunday, Vitesse had the chance to reduce the Amsterdammers' advantage to three points.
But they found themselves trailing to Jurgen Locadia's seventh-minute strike and, although Zakaria Labyad equalised in the 18th minute, Memphis Depay put PSV ahead again before the half-hour mark and that was how it remained.
Elsewhere on Saturday, Heracles Almelo lifted themselves clear of the relegation zone - and to the brink of the final Europa League play-off berth - with a 2-1 home win over Roda JC.
Bryan Linssen netted towards the end of each half to turn the game in Heracles' favour after Guus Hupperts' 14th-minute opener had put the basement boys ahead.
ADO Den Haag also enjoyed a 2-1 home victory - at the expense of 10-man FC Groningen.
Roland Alberg's 63rd-minute penalty put ADO in the ascendancy after Eric Botteghin's red card and, although Richairo Zivkovic restored parity 12 minutes from time, Dion Malone grabbed a late winner to give the hosts breathing space in their battle for survival.