PSV Eindhoven ended their winter break in dismal fashion as they were upset 3-1 at home by lowly PEC Zwolle, finishing the match with 10 men.
Erik Pieters' return from nine months out with injury was cut short by a red card in the 67th minute, but by the time he departed following a poor challenge from behind on Fred Benson, all four goals had already been scored.
Benson got two of them, putting Zwolle ahead courtesy of some poor defending in the 25th minute and then, after Tim Matacz levelled three minutes before half-time, he put Zwolle back in front nine minutes into the second half after another defensive mix-up.
Wiljan Pluim added a third in the 63rd minute to give Zwolle a rare victory in Eindhoven, and the frustration got to Pieters moments later.
Reports in Holland after the match said Pieters had been taken to hospital after punching a window in anger and cutting his hand.
The result means FC Twente have the opportunity to move three points clear by beating RKC Waalwijk on Saturday, while Ajax or Feyenoord will move level with them in second place if there is a winner between the two at the Amsterdam ArenA on Sunday.