FC Twente will be unable to call on the services of Marko Arnautovic for their trip to Arsenal.
The Eredivisie outfit head to Emirates Stadium on Wednesday 2-0 down from the first leg of their UEFA Champions League qualifying contest.
Steve McClaren will be aware that his side face an arduous task if they are to prolong their stay in Europe's premier club competition, and will be disappointed to see one of his young stars ruled out.
Arnautovic picked up a hamstring injury while representing Austria's Under 21 side in a friendly against Republic of Ireland last week.
He completed a full 90 minute run out in that fixture, but is now expected to be sidelined for several weeks.
The news that the 19-year-old is unavailable for the trip to North London causes a further headache to McClaren, with the former England boss already set to be without suspended Swiss striker Blaise Nkufo.