Bayern Munich made it a record-breaking start to the Bundesliga season by routing Fortuna Dusseldorf 5-0 to claim an eighth successive win, while Eintracht Frankfurt beat Hannover.
Looking to beat their own record of seven straight wins from the season's outset, Bayern emphasised their current superiority in German football with Mario Mandzukic and Luiz Gustavo giving them a two-goal advantage at half-time.
Thomas Muller added two more for the record German champions and Rafinha rounded off the comprehensive victory in the 87th minute of a one-sided game.
Defending champions Borussia Dortmund slipped further behind rampant Bayern after they were stunned 2-1 by Schalke in the Revier derby.
Ibrahim Afellay and Marco Hoger scored the goals for Huub Stevens' side, who emerged triumphant in the 141st derby encounter between the two sides, with Poland striker Robert Lewandowski's effort proving scant consolation.
Fourth-placed Dortmund are now 12 points adrift of Bayern as well as five behind Schalke in third place and their grip on their title already appears to be slipping after just eight games.
Eintracht Frankfurt bounced back from their first defeat of the season to see off Hannover 3-1 and remain five points adrift of Bayern in second.
The hosts were defeated by Borussia Monchengladbach before the international break but looked firmly on course to return to winning ways after Karim Matmour and Sebastian Jung put them 2-0 ahead.
Although Mohammed Abdellaoue pulled a goal back for Hannover shortly before the break, Alexander Meier made the points safe for Eintracht with eight minutes to go.
Gonzalo Castro's 87th-minute strike rescued a 2-2 draw for Bayer Leverkusen at home to Mainz.
Stefan Kiessling put Leverkusen ahead just before half-time but Adam Szalai and Marcel Risse turned the game on its head before Castro struck late on to ensure the points were shared.
Daniel Caligiuri's strike five minutes before the interval and Julian Schuster's goal in the 84th-minute goal gave Freiburg their first win on the road at rock-bottom Wolfsburg, who suffered their fourth successive defeat.
Werder Bremen won the battle of the Bundesliga's current under-achievers, defeating Borussia Monchengladbach 4-0 at the Weser Stadion.
Nils Petersen and Marko Arnautovic put Thomas Schaaf's men on the way to three points with goals just before half-time and Niclas Fullkrug and Zlatko Junuzovic wrapped up the win late in the second half.