Arminia Bielefeld stunned Bayern Munich with a shock 2-1 win to record their first victory of the season.
Things looked good for Bayern when Mark van Bommel fired them in front after just three minutes but Artur Wichniarek drew the home side level on 25 minutes.
Jonas Kamper grabbed the winner for Arminia seven minutes from time to inflict the first defeat of the season on Bayern.
Werder Bremen ended a miserable week after losing 3-2 at home to Stuttgart.
Werder were gifted the lead when Roberto Hilbert put through his own net after just four minutes and Mohamed Zidan doubled the lead on 33 minutes.
Hilbert made amends for his own goal by pulling a goal back for Stuttgart five minutes later and Pavel Pardo drew the visitors level just before the hour mark.
Mario Gomez completed the comeback with the winner for Stuttgart two minutes from time.
Nurnberg remain top of the table after a 1-1 draw with Bochum.
Theofanis Gekas gave Bochum a shock lead on ten minutes, but Jan Polak ensured Nurnberg picked up a point with a 30th minute leveller.
Borussia Dortmund continued their promising start to the season with a 1-0 win over Hamburg.
Dede netted the only goal of the game on 81 minutes.
Energie Cottbus moved into the top half of the table with a 2-0 victory over Mainz.
Second half goals from Sergei Radu (49) and Vlad Munteanu (59) were enough to give Energie the spoils.
Alemania Aachen recorded an impressive 4-2 win over Borussia Monchengladbach.
Aurel Reghecampf gave the hosts an early lead after seven minutes from the penalty spot and Jan Schlaudraff doubled the lead on the half hour mark.
Carlos Kahe reduced the arrears five minutes after the break, but Marius Ebbers restored the two-goal cushion a minute later.
Schlaudraff added a fourth goal five minutes from time and although Kahe netted his second of the contest in the last minute it was nothing more than a consolation.
Click on fixture for full match summary:
Alemania Aachen 4-2 Borussia Monchengladbach
Arminia Bielefeld 2-1 Bayern Munich
Borussia Dortmund 1-0 Hamburg
Energie Cottbus 2-0 Mainz
Nurnberg 1-1 VFL Bochum
Werder Bremen 2-3 Stuttgart