Inter Milan celebrated their fourth successive Serie A crown with a comfortable home win against Siena.
Bologna, Reggina and Torino secured important wins in the battle to avoid relegation from Serie A as Lecce slipped to the bottom of the table.
Fiorentina closed to within a point of third-placed Juventus in the race for automatic UEFA Champions League qualification as Genoa faltered.
Inter Milan celebrated their coronation as Serie A champions in style as they cruised to a 3-0 home victory over Siena.
City rivals AC Milan's defeat at Udinese on Saturday ensured that Jose Mourinho tasted success in his first season at the helm as Inter claimed the crown for a fourth season.
Esteban Cambiasso broke the deadlock on the stroke of half-time with Mario Balotelli making it 2-0 early in the second half.
Star striker Zlatan Ibrahimovic then completed the scoring 14 minutes from time as the Nerazzurri supporters continued their celebrations.
Lecce dropped to the foot of the table after suffering a last-gasp 2-1 defeat at fellow strugglers Bologna, who remain in the drop zone.
The visitors took the lead through Simone Tribocchi on the half-hour mark, but Bologna levelled on 37 minutes through top scorer Marco Di Vaio's close-range finish.
Dimitrios Papadopoulos was sent off for Lecce five minutes into the second half and Bologna stole the points in the fourth minute of stoppage-time after Di Vaio played in Sergio Volpi for the winner.
Torino kept themselves out of the bottom three after coming from behind to secure a 2-1 victory at Napoli.
Inacio Pia fired Napoli into a 42nd minute lead, but Rolando Bianchi equalised early in the second half from Roberto Stellone's knock-down.
The winner arrived on 72 minutes when Alessandro Rosina found the top corner with a stylish free-kick.
Reggina are still in with a shout of avoiding the drop after moving off the foot of the table courtesy of a 2-1 win at home to Cagliari.
Andrea Lazzari put Cagliari in front on 18 minutes, only for Reggina to level just eight minutes later through Fabio Ceravolo.
Relegation-threatened Reggina secured just a sixth league win of the campaign four minutes after half-time when Francesco Cozza set up Franco Brienza to score.
Juventus remain in third place in the standings after Claudio Ranieri's side were involved in an exciting 2-2 draw with Atalanta, with all the action coming in the first half.
Cristiano Doni set up Luca Cigarini to give Atalanta the lead after just two minutes before Nicola Legrottaglie headed against the bar for Juventus on 25 minutes.
Within 60 seconds, Juve were ahead after Vincenzo Iaquinta headed home Pavel Nedved's cross and almost took the lead two minutes later after Amauri's header came back off the woodwork.
Juve did nose in front on 36 minutes thanks to Cristiano Zanetti's strike, but Atalanta hit back a minute before half-time through Maximiliano Pellegrino's header.
Fiorentina could yet pip Juve for third spot after reducing the gap to a point following a 1-0 win at home to Sampdoria.
The only goal arrived on 21 minutes when Alberto Gilardino finished smartly from Juan Vargas' cross.
Genoa are now likely to miss out on a Champions League place after being held to a 2-2 draw at home to Chievo Verona.
The away side took a 35th-minute lead through Giampiero Pinzi, but Genoa levelled on 58 minutes through Diego Milito's penalty after the striker had been brought down by Mario Yepes.
Ruben Oliveira's free-kick gave Genoa the lead on 71 minutes, only for Chievo to snatch a point five minutes from time through Sergio Pellessier's header.
Palermo moved up to seventh in the table after a 2-0 home win over Lazio, with Fabrizio Miccoli and Giulio Migliaccio grabbing the goals.
Miccoli opened the scoring from the penalty spot on six minutes after he was brought down by Aleksandar Kolarov and Migliaccio made the game safe by heading home Fabio Simplicio's 87th minute free-kick.