Inter Milan stole derby day bragging rights with a 2-1 victory over AC Milan at the San Siro.
David Beckham's first taste of one of the world's great derbies ended in disappointment as Inter further extended their advantage at the Serie A summit.
Goals from Adriano and Dejan Stankovic put Jose Mourinho's Inter firmly in control before Alexandre Pato made for a nervy finish when he registered with 20 minutes still left to play.
Juventus missed a glorious opportunity to make ground on the Serie A leaders as they dropped points at home to Sampdoria.
Claudio Ranieri's Juve side would have been confident going into the game against Sampdoria, in fifteenth position prior to kick-off, but on the day they failed to fire after falling behind at Stadio Olimpico.
Giampaolo Pazzini gave Samp a 20th minute lead but it was an advantage they could hold onto only until just past the hour mark, when the prolific Amauri earned Juve a share of the spoils.
Sampdoria were not the only side to drop points after taking the lead as neighbours Genoa were guilty of squandering a three-goal advantage at home to Fiorentina.
Genoa took the lead through Thiago Motta before defying numerical disadvantage, when Giuseppe Biava was dismissed in the 38th minute, to forge further ahead.
Further efforts from Raffaele Palladino (38) and Diego Milito (56) had Genoa cruising but Adrian Mutu had other ideas as his stunning hat-trick earned the Viola a share of the spoils.
The Romanian got the first from the penalty spot on the hour mark before goals in the 80th and final minute concluded the scoring.
Roma endured an afternoon to forget on their travels to Atalanta as they returned to the capital with only a 3-0 defeat for their efforts.
Daniele Capelli got Atalanta off the mark in the 52nd minute before quickfire efforts from Cristiano Doni (56 & 59) secured an excellent day's work.
Cagliari were too strong at home to Lecce as second half strikes from Michele Fini and substitute Alessandro Matri, in the final minute, secured a comfortable 2-0 win.
Giuseppe Colucci was another substitute who struck in the last minute, as his goal for Chievo cancelled out Pablo Ledesma's early penalty for Catania.
Massimo Maccarone's second goal in as many games gave Siena a 50th minute lead against Udinese, but it was not enough for a maximum haul as Antonio Di Natale conjured a 72nd minute leveller.
Reggina and Palermo could not manage a goal between them.