Juventus' game at AC Milan will take centre stage this weekend in Italian football while 24 hours earlier in the capital city, scudetto contenders Roma host Inter Milan in a glamorous tie.
Defending champions Juve will be looking to cap off a great week with a win at a sold-out Giuseppe Meazza stadium on Sunday night.
Juve followed last weekend's 1-0 triumph over Torino in the Turin derby with Thursday's 2-0 at Trabzonspor to set up a last 16 Europa League meeting with Fiorentina.
"We've got little time to prepare for the game in Milan," Juve coach Antonio Conte said. "We will have just one training session.
"But we are Juve, we will have to be smart and use not only with our legs but our head.
"The recipe is the same as that of the derby, to keep a cool head and play with heart."
Milan head into the contest in ninth place, 31 points behind Juve and having to do without injured striker Mario Balotelli.
Roma trail nine points behind Serie A leaders Juve but have a game in hand.
The Giallorossi boast the best defensive line in the competition with just 11 goals given away and take on an Inter side that has mustered just six goals this year.
Roma will have three sections of the Stadio Olimpico stadium - where their ultra fans traditionally sit - closed on Saturday as punishment for their supporters' misbehaviour.
Napoli are third in Serie A and head into Sunday's game at relegation-threatened Livorno having to do without the team's top scorer Gonzalo Higuain through suspension.
Higuain scored in his team's 3-1 triumph against Swansea in midweek, a result which allowed Napoli to continue their European adventure.
Fourth-place Fiorentina also progressed in the continental competition after completing a 4-2 aggregate win over Esbjerg on Thursday.
The Viola host a Lazio team that will be looking to bounce back from its painful elimination in the Europa League.
Lazio drew 3-3 at Ludogorets on Thursday but lost 4-3 on aggregate.
Victory against Bologna would all but guarantee Hellas Verona Serie A football next season.
Hellas gained promotion to Italy's top flight last summer and have collected 39 points in 25 games.
In-form Parma are riding a 14-game unbeaten run and play away at bottom-side Sassuolo.
Genoa will fancy their chances of taking a good result against Catania with the Grifoni having lost just one of their last nine games at home.
Chievo square off against Atalanta in Verona invigorated by last weekend's 2-0 triumph over Catania, their first victory since December 8.
Cagliari have lost three of their last four matches in Sardinia and host Udinese looking to rediscover their winning touch at the Sant' Elia stadium.
Sampdoria will not be at full strength for Sunday's game at Torino with defenders Angelo Palombo and Andrea Costa as well as striker Maxi Lopez all suspended.