Leaders AC Milan took another important step towards the Serie A title with a 3-0 home victory over struggling Sampdoria on Saturday.
The Rossoneri took the lead over the relegation-threatened visitors through Clarence Seedorf on 20 minutes before Antonio Cassano converted from the spot early in the second half after a contested handball.
Brazilian ace Robinho wrapped up the win with a third in the 61st minute to hand Milan a boost in their bid for the trophy.
Sampdoria now face the prospect of slipping into the bottom three on Sunday, depending on results.
Troubled champions Inter are now eight points adrift of neighbours Milan with five games remaining following their shock 2-0 defeat at lowly Parma.
Midfielder Sebastian Giovinco did the damage for the home side early on before Brazilian veteran Amauri sealed the triumph five minutes from time.
The third-placed Nerazzurri's hopes of a sixth-straight Scudetto are almost over after the defeat, which follows their UEFA Champions League exit to Schalke in midweek.
Sixth-placed Roma, taken over by an American consortium on Friday, suffered a late 3-2 home defeat by Palermo to hit their Champions League chances.
Abel Hernandez grabbed his second of the match in stoppage time to clinch the three points for the visitors.