Palermo collected only a point after being held to a draw by 10-man Sampdoria.
A win would have moved Palermo three points clear of third place Lazio who travel to Cagliari on Sunday.
Sampdoria's hopes of an upset faded on 36 minutes when Giulio Falcone was sent off for a professional foul.
Things went from bad to worse when Edinson Cavani put the visitors ahead shortly after half-time.
However, Samp were not to be denied and Fabio Quagliarella's (pictured) goal snatched a share of the spoils.
Click below for match summary:
Sampdoria 1-1 Palermo