Internazionale defeated Fiorentina 2-0 to stay four points clear at the top of Serie A, but Roma kept the pressure on with a 3-1 victory over Udinese.
High-flying Fiorentina held Internazionale at bay in the first half but the deadlock was broken ten minutes after the restart as Esteban Cambiasso struck.
Mario Balotelli then scored seven minutes later to keep up his recent good form and secure the win for Inter.
Luciano Spalletti's Roma had closed the gap on Inter earlier on Sunday after coming from a goal down in their encounter against Udinese .
Antonio Di Natale opened the scoring in the 51st minute, but Mirko Vucinic restored parity 13 minutes later.
Rodrigo Taddei then put Roma in front before Ludovic Giuly put the icing on the cake in the dying seconds.
Reggina climbed off the bottom of the table as Franco Brienza claimed the only goal of the game against Sampdoria.
Cagliari moved out of the relegation places with their 2-1 success at Livorno.
Fabio Galante put the home side in front, but a brace from Robert Acquafresca secured a crucial win for the visitors.
Empoli fell into the drop zone following their 1-1 draw with fellow strugglers Parma.
Cristiano Lucarelli handed the away side the lead, however Sebastian Giovinco ensured both sides claimed a point.
Lazio were denied victory as Siena struck a late leveller at the Stadio Olimpico.
Massimo Mutarelli's 45th minute effort appeared to be enough for the home side, but Simone Loria netted for Siena with two minutes remaining.
Napoli secured a 2-0 victory over Atalanta, with Marek Hamsik and Roberto Sosa both on target for the home team.