AC Milan will begin the post-Massimiliano Allegri era when they take on Spezia in Wednesday's Coppa Italia last 16 match.
The Rossoneri ended Allegri's three-and-a-half year reign with the club 30 points behind leaders Juventus after Sunday's humiliating 4-3 loss at Sassuolo.
Assistant coach Mauro Tassotti will take temporary charge of the team as the club begins the search for a permanent replacement.
Allegri is gone but not forgotten.
"I am absolutely saddened for Allegri and for how things have turned out," AC Milan vice-president Adriano Galliani said to acmilan.com.
"This is football. I have spoken to the club."
Rivals Spezia, who are alongside Siena as the only non-Serie A club left in the competition, travel to the San Siro also on the back of a disappointing defeat.
Sunday's 4-1 home reverse to Latina dropped the Liguria club to 12th in Serie B.
Cup holders Lazio welcome Parma to the Stadio Olimpico on Tuesday.
The Biancoceleste go into the match with coach Edy Reja having announced that he will make wholesale changes to the side that held Bologna to a goalless result at the weekend.
Lazio can expect a stern test with Parma in fine fettle.
The Ducale club followed their 3-1 triumph over Torino with a 3-0 triumph at Livorno last time out.
Napoli go into Wednesday's match against Atalanta looking to keep their impressive start to 2013.
Rafa Benitez's men upset Sampdoria 2-0 before taking a 3-0 triumph at Hellas Verona on Sunday.
Napoli are third in the table and hold the last Champions League qualifying spot.
Rivals Atalanta halted a two-month winless run with a 2-1 triumph over Catania.
Catania coach Luigi De Canio is set to rest his top players in Wednesday's match against Siena in view of Sunday's game against Fiorentina.
The Sicilians lie at the foot of the Serie A standings, three points behind safety.
Siena were held to a 1-1 draw by Varese at the weekend and lie 14th in Serie B.