Roma midfielder Daniele de Rossi will be sidelined for at least two weeks after picking up an ankle injury in the 2-1 win over Messina on Sunday.
De Rossi was substituted with just a few minutes of the game remaining and immediately transferred to a clinic, where scans confirmed ligament damage and the two week lay-off.
The news is another massive blow for Roma coach Luciano Spalletti, whose hopes of UEFA Champions League qualification could be dashed by a lengthy casualty list.
De Rossi had already guaranteed himself the headlines before suffering the injury, courtesy of his sportsmanship earlier in the match.
The midfielder had appeared to score his fifth goal of the Serie A season, but then notified the referee that the ball had come off his hand, meaning that the strike was disallowed.
Both Spalletti and Messina coach Bortolo Mutti praised his actions, but Mutti did feel that de Rossi was lucky to escape without a yellow card.
"De Rossi's fair play was a really positive thing. And in this case it was backed up by the referee, who didn't book him," said Spalletti.
"The gesture was very honest, but the rules are clear and he had to be booked," countered Mutti.