Udinese joined AC Milan at the top of the table while Napoli brushed aside lowly Lecce in Serie A.
Udinese are joint-top of Serie A with the Rossoneri following 1-0 victory over Inter Milan at Giuseppe Meazza.
Mauricio Isla scored the only goal 17 minutes from the end of a dramatic game which saw both teams miss penalties inside the final 10 minutes and finish the game a man light.
Inter's Javier Zanetti was first to see red when he gave away a penalty which was saved by Julio Cesar, while Damiani Ferronetti followed him into the dressing room five minutes later having moments earlier conceded a penalty which Giampaolo Pazzini missed at the other end.
Inter's sixth defeat of the season sees them fall 13 points behind Udinese, who join Milan on 27 points at the summit but stay second due to inferior goal difference.
Napoli warmed up for their vital UEFA Champions League tie with Villarreal by brushing past basement boys Lecce 4-2.
Knowing that a win over the Spaniards will see them through to the knockout stages of the tournament, Walter Mazzarri's men ensured they will head into that clash full of confidence thanks to this four-goal show at Stadio San Paolo.
They may have some concerns over their defence, though, with Luis Muriel and Daniele Corvia scoring for Lecce, although those goals were only consolations at 3-1 and 4-2.
By those points, Ezequiel Lavezzi, Edison Cavani (two) and Blerim Dzemaili had put the game out of sight for the home side.