Athletic Bilbao eased the pressure on coach Mane with a 2-0 win over high-flying Getafe.
The Basque club are languishing near the foot of the table, but they boosted their hopes of avoiding the drop as an Aritz Aduritz brace proved enough to see off the challenge of Getafe.
Racing Santander heaped more misery on Gimnastic de Taragona with a 4-1 win at El Sardinero.
Nastic, who are propping up the table, had the temerity to take the lead just before the hour mark through Tobias Grahn.
It proved to be a false dawn, however, as Racing were on level terms 60 seconds later thanks to Lionel Scaloni.
Anibal Matellan put the ball through his own next on 67 minutes and late goals from Gonzalo Colsa and Nikola Zigic (pictured) sealed the win for Racing.
Celta Vigo were another struggling side to claim a victory, as an early goal from Fernando Baiano secured three points at Osasuna.
The wins for Celta and Athletic added to the woes of Real Sociedad who slipped to a 1-0 defeat at Recreativo de Huelva.
Roberto Beto's goal ensured Sociedad are now 11 points adrift of safety.
Luis Garcia was on target twice as Espanyol claimed a 3-1 win over Real Mallorca.
Garcia's brace sandwiched an effort from Bosko Jankovic for Mallorca, while Eduardo Costa netted a late third deep in injury-time to cap a fine day for Espanyol.
Deportivo La Coruna endured a frustrating afternoon as they were held at home by Levante.
Sevilla take on Atletico Madrid and Barcelona travel to Valencia later on Sunday, with all the action available live on Sky Sports 1.
Click below for a match summary:
Athletic Bilbao v Getafe
Deportivo La Coruna v Levante
Espanyol v Mallorca
Osasuna v Celta Vigo
Racing Santander v Gimnastic
Recreativo Huelva v Real Sociedad
Sevilla v Atletico Madrid
Valencia v Barcelona