Espanyol were comfortable winners over Livorno claiming a 4-1 aggregate success.
The Spanish were favourites to progress to the last 16 and they made no mistake with a 2-0 win at the Olympic Stadium in Barcelona.
Jesus Lacruz opened the scoring as he pounced after just 16 minutes in.
The result, which was not in doubt, was sealed just moments into the second period when Ferran Corominas fired home.
Livorno's night was compounded late on when Cesar was dismissed.
They will meet Maccabi Haifa in the next round.
Click below for match summary:
Espanyol 2-0 Livorno (4-1 agg)