Valencia's injury jinx struck again on Thursday as Mario Regueiro tore knee ligaments in a training session.
The Uruguayan international winger is now facing six to seven months on the sidelines and joins a further nine Valencia team-mates in the treatment room at the Mestalla.
Regueiro tore the cruciate ligament in his left knee after an accidental collision with Ruben Baraja in a training session.
He was immediately transferred to hospital where the club's worst fears were confirmed following tests on the affected knee.
"A sporting accident has caused the cruciate ligament in his left knee to tear," confirmed Valencia's medical staff.
Regueiro becomes the latest in a long line of Primera Liga players to sustain a serious knee ligament injury and the third at Valencia this season.
Midfielders Jaime Gavilan and Edu have both been struck down by identical problems, while David Albelda, Carlos Marchena and Emiliano Moretti have suffered ligament damage of a less serious nature.
The Che's injury problems are reaching crisis point ahead of this weekend's league clash with Recreativo de Huelva with first-choice strikers David Villa and Fernando Morientes also currently sidelined.