Tito Vilanova has expressed his gratitude to Barcelona's players, staff and fans for the support shown to him throughout his reign.
The 44-year-old stepped down as head coach on Friday night with the club revealing that he would not be able to carry on in his role as he continues to receive cancer treatment.
In an open letter published on the club's official website, Vilanova wrote: "After five wonderful years as part of a team that has made dreams come true for any coach, it's time to face a change in my professional life and focus my energy on continuing to fight the disease I was diagnosed with a year and a half ago.
"The doctors recommend that, with the treatments that I must follow from now on, I cannot devote 100 per cent to the tasks of head coach as required by FC Barcelona. But I will continue to work closely for the club that I love on other sporting tasks."
Vilanova was Pep Guardiola's assistant before being promoted to the top job last summer when the record-breaking coach decided to take a one-year sabbatical from the game.
In his one campaign in charge of the club, Vilanova led Barca to their fourth Primera Division title in five years, becoming only the second team after Real Madrid to reach the 100-point mark.
"It is not easy to leave this very special group of players, fellow staff and friends with whom I shared many memorable experiences," he added.
"I'll be eternally grateful for everything you have given me and the affection you have shown.
"I also want to especially thank the president (Sandro Rosell), the board and sporting director Andoni Zubizarreta for the confidence they put in me and, above all, the unconditional support, both sporting and personal.
"Equally important to me is the support I receive - both medical and humane - from Dr Ramon Canal and his team of doctors who are on my side. I do not play this game alone, but as part of a supportive club that will help me succeed in this long process, as it has done until now.
"To all of you, members and fans of the club, I also want to thank you wholeheartedly for the support and affection that you have shown - not just now but over the last few months.
"I can tell you I'm calm, strong and that I start this new stage in my recovery with full confidence that all will be well."