Sevilla have been rocked by the news that Renato and Jesus Navas will be sidelined for at least three weeks.
Spain international winger Navas suffered an ankle injury during Thursday's 1-0 defeat to Paris St Germain in the Europa League.
Brazilian midfielder Renato sat out the match after picking up a knee problem in training and scans have now confirmed he will be out until October.
Renato and Navas are therefore likely to miss four Primera Liga games, as well as the next European clash against Borussia Dortmund.
They could then be looking to return to action when Sevilla face Sporting Gijon on 17th October after the international break.