Ligue 1 heavyweights Paris Saint-Germain and Marseille meet on Wednesday in what is the standout tie of the last 16 of the Coupe de la Ligue.
PSG are currently top of the league, three points ahead of third-placed Marseille who have a game in hand after their match with Lyon on Sunday was postponed due to high winds.
OM are the current cup holders after their 1-0 extra-time victory over Lyon in April, with Brandao's goal sealing their third successive triumph in the competition.
While Elie Baup's side will be targeting their fourth cup on the trot, PSG are looking for their first since 2008 with silverware very much on the agenda in the capital.
France defender Mamadou Sakho told psg.fr: "This year we are really determined to win something, so the cup and the championship are in our sights.
"We are still dreaming of a title. So we will really play to win domestic cups.
"We will give everything to go as far as possible."
While the teams are expected to be among the major challengers for the league, the 22-year-old does not believe the cup game will be any less demanding.
"It will be a game with a lot of intensity. OM is a great team of key players, so I expect a good game. It is a Classico, there will be a lot of duels, we will have to be ready."
OM captain Steve Mandanda rued the postponement of the match at the Stade Velodrome but admitted there were benefits, given they had more rest than their opponents.
He said: "It's frustrating, we would have preferred to play. We had prepared since Friday.
"Now there is a match ahead on Wednesday. It was a day of rest and we will be able to prepare in the best way possible."
While the match in the capital is the most enticing, second-placed Toulouse's visit to 2011 league champions Lille on Tuesday is intriguing.
Lille may only be 10th in Ligue 1, five points behind their visitors, but they demonstrated their spirit when they bounced back from their Champions League defeat against Bayern Munich to beat Valenciennes for whom victory would have propelled them into the top four.
This followed a 1-1 draw with Bordeaux for Rudi Garcia's team who reached the quarter-finals last season.
Montpellier have shown little of the form which guided them to last year's league title although they go into Wednesday's match against Bordeaux on the back of their first home win of the season after beating Nice on Saturday.
Bordeaux travel to the Stade de la Mosson in eighth, five places ahead of their hosts.
There are three other matches on Tuesday.
St Etienne are favourites to win in Sochaux, Ligue 2 Monaco could well spring a surprise on Ligue 1 strugglers Troyes while Rennes should progress at the expense of Arles.
As well as the games at PSG and Montpellier on Wednesday, last season's beaten finalists Lyon visit Nice and Bastia host Auxerre.