Jeremy Toulalan will miss Lyon's clash against Benfica with a foot injury, according to his coach Claude Puel.
The France international was withdrawn after 36 minutes during the 3-1 win over Lille on Sunday after complaining about a pain in his right foot.
And it would appear he will be sidelined until early November when the two sides meet again in the UEFA Champions League.
"He has been ruled out until at least the return game in Portugal," Puel told a news conference on Tuesday.
Lyon currently top Group B with six points from two games after defeating Schalke 04 and Hapoel Tel Aviv.