Lille boss Claude Puel has been hit by injuries to Jean Makoun and Abdul Kader Keita.
Makoun has returned from international duty with Cameroon with thigh trouble, and looks set to miss this weekend's clash with Valenciennes.
Keita is also struggling with a thigh problem and has been rated as doubtful.
Yohan Cabaye picked up an ankle problem whilst playing for France's Under 21s on Tuesday and is likely to be sidelined for a month.
Stephane Dumont is also out with a shoulder injury, but Puel will be hoping the mounting casualty list does not affect his side's push for UEFA Champions League qualification.