Midfielders Mathieu Bodmer and Yohan Cabaye have been ruled out of Lille's UEFA Champions League clash against Manchester United.
Bodmer started the first leg in France but has since suffered an ankle injury.
Cabaye, who came on as a substitute against United, has not managed to recover from a stomach muscle tear.
"Both are out of the game," Lille coach Claude Puel confirmed to reporters.
Manchester United have a 1-0 lead to protect in the second leg on Wednesday following Ryan Giggs' controversial free-kick at Stade Felix-Bollaert.
Lille have twice complained to Uefa that Giggs' goal should have been disallowed but their appeals have been rejected.