Lyon extended their lead in Ligue 1 after a 1-0 home win over Montpellier on Saturday, while Paris Saint-Germain lost 2-1 at Nice.
Lyon's Bafetimbi Gomis - hat-trick hero in the midweek 4-1 win at Marseille - continued his fine form by hitting the only goal of the game at the Stade de Gerland after 26 minutes.
The result ended Les Heraultais' five-game unbeaten run in the league, leaving the visitors too close to the relegation zone for comfort.
Nice dealt a blow to PSG's title hopes with a 2-1 victory in a game which came to life in the closing 15 minutes.
Zlatan Ibrahimovic appeared to have earned the big spending capital side a draw in the 82nd minute, six minutes after Eric Bautheac had given Nice the lead.
However, Valentin Eysseric's impressive right-foot volley won it for Nice, inflicting a first away defeat of the season on Carlo Ancelotti's men.
A late free-kick from Rafael Dias meant Bordeaux dropped what could be two vital points in their pursuit of Champions League football after they drew 2-2 with relegation-threatened Sochaux.
A Loic Poujol strike had put the visitors in front at the Stade Jacques Chaban-Delmas before a Jerome Roussillon own goal brought the hosts level.
A second-half strike from Yoan Gouffran put Francis Gillot's side in front against his old club.
However Dias popped up with just three minutes from time to earn a point for Sochaux, who dropped into the bottom three, while Bordeaux are now sixth, but just one point off the Champions League places.
Nancy's winless run was extended to 15 games as they remained rooted to the bottom of the table following a 1-1 draw at Evian.
Brice Dja Djedje's clever finish sent Evian ahead just before half-time but Nancy, without a league win since the opening day, clawed themselves back into the contest through Yohan Mollo five minutes after the restart.
A long overdue win never looked like arriving, however, as Evian came closest to maximum points when Daniel Wass crashed a shot against the crossbar.
Valenciennes climbed to fifth in the standings as Foued Kadir's early goal saw off Reims 1-0.
Kadir struck after only six minutes to settle the encounter at the Stade Nungesser in the hosts' favour, despite the visitors dominating thereafter.
Lille and Bastia played out a dour 0-0 stalemate at the Grand Stade Metropole.
Dimitri Payet's free-kick against the post in the first half was as good as it got in terms of goalmouth action, with the hosts controlling the game but unable to take advantage.