Lille earned a 1-0 first leg win over Sevilla in their Uefa Cup clash.
Geoffrey Dernis's first-half goal proved to be enough to give Lille the victory.
The French side, who dropped into the Uefa Cup after failing to qualify for the knock-out stages of the UEFA Champions League, dominated for large periods of the game.
Matt Moussilou was unlucky not to break the deadlock after just 14 minutes when he struck the post.
Lille did grab the opener on 24 minutes when Sevilla goalkeeper Antonio Notario misjudged Dernis's corner, allowing it to fly directly into the net.
Fredi Kanoute posed the greatest threat for Sevilla, but the former West Ham United and Tottenham Hotspur star could not find a crucial away goal for Sevilla, as Lille held on for the win.
Zenit St Petersburg stunned Marseille with a priceless 1-0 win over the French giants at Stade Velodrome.
Andrei Arshavin grabbed the only goal of the game on 51 minutes to give the Russians the crucial away goal.
Marseille suffered a major blow 20 minutes from time when Franck Ribery was sent off for a second bookable offence, meaning he will miss the return leg next week.
Basel moved a step closer to the quarter finals of the Uefa Cup with a 2-0 win over Strasbourg.
Matias Delgado gave Basel the ideal start with the opener after just eight minutes.
The Swiss side doubled their lead in the final minute through Zdravko Kuzmanovic to set them up nicely for the second leg in France next week.